The sixth-ranked Oklahoma State Cowboys remained perfect on the season defeating Missouri 45-24 despite Justin Blackmon leaving the game before half-time with an injured shoulder.

Joseph Randle had a big game for the pokes scoring four touchdowns, two on runs that capitalized on big defensive plays by linebacker Shaun Lewis. With the win Oklahoma
State snapped Missouri’s 10-game home winning streak.

Randle had 138 yards rushing on 14 carries and scored on runs of 16, 59 and 12 yards.  His other touchdown came on a 13-yard touchdown pass in the second quarter.

OSU quarterback Brandon Weeded had three touchdown passes after the opening snap in the second quarter despite injuries to both starting wide receivers.

Justin Blackmon caught a touchdown pass in the first quarter before hurting his shoulder, while Hubert Anyiam was wearing a boot on his left foot in the second half.

Weeden ended the game 33 of 49 for 338 yards, after a hot start. The 28-year-old senior was 19 of 25 for 214 yards in the first quarter, with all six incompletions coming on dropped passes.

Missouri sophomore running back Henry Josey continued his strong season as he rushed for 138 yards on 25 carries while teammate T.J. Moe had six catches for 103 yards and a score.

The Tigers had a strong second quarter, scoring on an 18-yard run by Kendial Lawrence and Moe's 34-yard catch from quarterback James Franklin to cut the deficit to seven, before being undone by mistakes. Franklin threw two interceptions and lost a fumble at the Oklahoma State 4, all in the second half.

Lewis intercepted a tipped pass at the Missouri 27 and three plays later Randle scored on a 16-yard run for a two-touchdown cushion midway through the third quarter.

The loss moved the Missouri to 3-4 on the year and 1-3 in Big 12 play; while Oklahoma State improved to 7-0 and 4-0 in conference games.