The U.S. Open men’s semifinal match-ups are set after Friday afternoon’s contests. Defending champion Rafael Nadal was dominant as he routed the last American man at the Open.

Nadal overwhelmed Roddick right from the start as he compiled a 22-0 edge in forehand winners, broke six times and never left the outcome of their match come in doubt, winning 6-2, 6-1, 6-3 to reach the semifinals at Flushing Meadows for the fourth consecutive year.

Nadal took the first four games in just 18 minutes. He then reeled off 16 of the last 17 points, which included 12 in a row, to close out the second set. He’s yet to drop a set heading into Saturday’s semifinal against No. 4 Andy Murray who beat No. 28 John Isner 7-5, 6-4, 3-6, 7-6 (2) earlier Friday.

The other semifinal match-up was set up by Thursday’s quarterfinals, and it will be a big one as No.1 Novak Djokovic will face No. 3 Roger Federer, who has won five of his record 16 Grand Slam championships at the U.S. Open.

For the second time in the last three major tournaments, the final foursome is filled by the top men ranked Nos. 1-4 – something that hasn’t happened at the U.S. Open since 1992.